脑图基础模型：跨多图谱与疾病的预训练和提示微调

ICLR 2026 Poster accepted paper at ICLR 2026. As large language models (LLMs) continue to revolutionize AI research, there is a growing interest in building large-scale brain foundation models to advance neuroscience. While most existing brain foundation models are pre-trained on time-series signals or connectome features, we propose a novel graph-based pre-training paradigm for constructing a brain graph foundation model. In this paper, we introduce the Brain Graph Foundation Model, termed BrainGFM, a unified framework that leverages graph contrastive learning and graph masked autoencoders for large-scale fMRI-based pre-training. BrainGFM is pre-trained on a diverse mixture of brain atlases with varying parcellations, significantly expanding the pre-training corpus and enhancing the model’s ability to generalize across heterogeneous fMRI-derived brain representations. Code/project link: https://github.com/weixinxu666/BrainGFM