搜索医学 AI 论文与资源

ICLR 2026 Poster accepted paper at ICLR 2026. The human brain is the most efficient and versatile system for processing dynamic visual input. By comparing representations from deep video models to brain activity, we can gain insights into mechanistic solutions for effective video processing, important to better understand the brain and to build better models. Current works in model-brain alignment primarily focus on fMRI measurements, leaving open questions about fine-grained dynamic processing. Here, we introduce the first large-scale model benchmarking on alignment to dynamic electroencephalography (EEG) recordings of short natural videos. We analyze 100+ models across the axes of temporal integration, classification task, architecture, and pretraining, using our proposed Cross-Temporal Representational Similarity Analysis (CT-RSA) which matches the best time-unfolded model features to dynamically evolving brain responses, distilling $10^7$ alignment scores.

ICLR 2026 Poster accepted paper at ICLR 2026. Learning from multi-variate time-series with heterogeneous channel configurations remains a fundamental challenge for deep neural networks, particularly in clinical domains such as intracranial electroencephalography (iEEG), where channel setups vary widely across subjects. In this work, we introduce multi-variate parallel attention (MVPA), a novel self-attention mechanism that disentangles content, temporal, and spatial attention, enabling flexible, generalizable, and efficient modeling of time-series data with varying channel counts and configurations. We use MVPA to build MVPFormer, a generative foundation model for human electrophysiology, trained to predict the evolution of iEEG signals across diverse subjects. To support this and future efforts by the community, we release the SWEC iEEG dataset, the largest publicly available iEEG dataset to date, comprising nearly 10,000 hours of recordings from heterogeneous clinical sources. Code/project link: https://github.com/IBM/multi-variate-parallel-transformer; https://huggingface.co/datasets/NeuroTec/SWEC_iEEG_Dataset

ICLR 2026 Poster accepted paper at ICLR 2026. Modeling neural population dynamics is crucial for foundational neuroscientific research and various clinical applications. Conventional latent variable methods typically model continuous brain dynamics through discretizing time with recurrent architecture, which necessarily results in compounded cumulative prediction errors and failure of capturing instantaneous, nonlinear characteristics of EEGs. We propose ODEBrain, a Neural ODE latent dynamic forecasting framework to overcome these challenges by integrating spatio-temporal-frequency features into spectral graph nodes, followed by a Neural ODE modeling the continuous latent dynamics. Our design ensures that the latent representations can capture stochastic variations of complex brain states at any given time point.

ICLR 2026 Poster accepted paper at ICLR 2026. Enabling natural communication through brain–computer interfaces (BCIs) remains one of the most profound challenges in neuroscience and neurotechnology. While existing frameworks offer partial solutions, they are constrained by oversimplified semantic representations and a lack of interpretability. To overcome these limitations, we introduce **Semantic Intent Decoding(SID)**, a novel framework that translates neural activity into natural language by modeling meaning as a flexible set of compositional semantic units. SID is built on three core principles: semantic compositionality, continuity and expandability of semantic space, and fidelity in reconstruction.

ICLR 2026 Poster accepted paper at ICLR 2026. Samples of brain signals collected by EEG sensors have inherent anti-correlations that are well modeled by negative edges in a finite graph. To differentiate epilepsy patients from healthy subjects using collected EEG signals, we build lightweight and interpretable transformer-like neural nets by unrolling a spectral denoising algorithm for signals on a balanced signed graph---graph with no cycles of odd number of negative edges. A balanced signed graph has well-defined frequencies that map to a corresponding positive graph via similarity transform of the graph Laplacian matrices. We implement an ideal low-pass filter efficiently on the mapped positive graph via Lanczos approximation, where the optimal cutoff frequency is learned from data.

ICLR 2026 Poster accepted paper at ICLR 2026. Tasks ranging from sleep staging to clinical diagnosis traditionally rely on standard polysomnography (PSG) devices, bedside monitors and wearable devices, which capture diverse nocturnal biosignals (e.g., EEG, EOG, ECG, SpO$_2$). However, heterogeneity across devices and frequent sensor dropout pose significant challenges for unified modelling of these multimodal signals. We present sleep2vec, a foundation model for diverse and incomplete nocturnal biosignals that learns a shared representation via cross-modal alignment. sleep2vec is contrastively pre-trained on 42,249 overnight recordings spanning nine modalities using a Demography, Age, Site & History-aware InfoNCE objective that incorporates physiological and acquisition metadata (e.g., age, gender, recording site) to dynamically weight negatives and mitigate cohort-specific shortcuts.

ICLR 2026 Poster accepted paper at ICLR 2026. Foundation models are reshaping EEG analysis, yet an important problem of EEG tokenization remains a challenge. This paper presents TFM-Tokenizer, a novel tokenization framework that learns a vocabulary of time-frequency motifs from *single-channel* EEG signals and encodes them into discrete tokens. We propose a dual-path architecture with time–frequency masking to capture robust motif representations, and it is model-agnostic, supporting both lightweight transformers and existing foundation models for downstream tasks. Our study demonstrates three key benefits: *Accuracy:* Experiments on four diverse EEG benchmarks demonstrate consistent performance gains across both single- and multi-dataset pretraining settings, achieving up to $11\%$ improvement in Cohen’s Kappa over strong baselines. Code/project link: https://github.com/Jathurshan0330/TFM-Tokenizer

ICLR 2026 Poster accepted paper at ICLR 2026. Interpreting clinical electroencephalography (EEG) is a laborious, subjective process, and existing computational models are limited to narrow classification tasks rather than holistic interpretation. A key bottleneck for applying powerful Large Vision-Language Models (LVLMs) to this domain is the scarcity of datasets pairing EEG visualizations with fine-grained, expert-level annotations. We address this by introducing CerebraGloss, an instruction-tuned LVLM for nuanced EEG interpretation. We first introduce a novel, automated data generation pipeline, featuring a bespoke YOLO-based waveform detector, to programmatically create a large-scale corpus of EEG-text instruction data. Code/project link: https://github.com/iewug/CerebraGloss

ICLR 2026 Oral accepted paper at ICLR 2026. Accurate analysis of Medical time series (MedTS) data, such as Electroencephalography (EEG) and Electrocardiography (ECG), plays a pivotal role in healthcare applications, including the diagnosis of brain and heart diseases. MedTS data typically exhibits two critical patterns: **temporal dependencies** within individual channels and **channel dependencies** across multiple channels. While recent advances in deep learning have leveraged Transformer-based models to effectively capture temporal dependencies, they often struggle to model channel dependencies. This limitation stems from a structural mismatch: ***MedTS signals are inherently centralized, whereas the Transformer's attention is decentralized***, making it less effective at capturing global synchronization and unified waveform patterns. Code/project link: https://github.com/Levi-Ackman/TeCh

ICLR 2026 Poster accepted paper at ICLR 2026. Epilepsy affects over 50 million people worldwide, and one-third of patients suffer drug-resistant seizures where surgery offers the best chance of seizure freedom. Accurate localization of the epileptogenic zone (EZ) relies on intracranial EEG (iEEG). Clinical workflows, however, remain constrained by labor-intensive manual review. At the same time, existing data-driven approaches are typically developed on single-center datasets that are inconsistent in format and metadata, lack standardized benchmarks, and rarely release pathological event annotations, creating barriers to reproducibility, cross-center validation, and clinical relevance. Code/project link: https://omni-ieeg.github.io/omni-ieeg/; https://github.com/Omni-iEEG/Omni-iEEG