搜索医学 AI 论文与资源

ICLR 2026 Poster accepted paper at ICLR 2026. Understanding the properties of neural populations (or voxels) in the human brain can advance our comprehension of human perceptual and cognitive processing capabilities and contribute to developing brain-inspired computer models. Recent encoding models using deep neural networks (DNNs) have successfully predicted voxel-wise activity. However, interpreting the properties that explain voxel responses remains challenging because of the black-box nature of DNNs. As a solution, we propose LLM-assisted Visual Cortex Captioning (LaVCa), a data-driven approach that leverages large language models (LLMs) to generate natural-language captions for images to which voxels are selective.

ICLR 2026 Poster accepted paper at ICLR 2026. The human brain is the most efficient and versatile system for processing dynamic visual input. By comparing representations from deep video models to brain activity, we can gain insights into mechanistic solutions for effective video processing, important to better understand the brain and to build better models. Current works in model-brain alignment primarily focus on fMRI measurements, leaving open questions about fine-grained dynamic processing. Here, we introduce the first large-scale model benchmarking on alignment to dynamic electroencephalography (EEG) recordings of short natural videos. We analyze 100+ models across the axes of temporal integration, classification task, architecture, and pretraining, using our proposed Cross-Temporal Representational Similarity Analysis (CT-RSA) which matches the best time-unfolded model features to dynamically evolving brain responses, distilling $10^7$ alignment scores.

ICLR 2026 Poster accepted paper at ICLR 2026. The development of foundation models for functional magnetic resonance imaging (fMRI) time series holds significant promise for predicting phenotypes related to disease and cognition. Current models, however, are often trained using a mask-and-reconstruct objective on small brain regions. This focus on low-level information leads to representations that are sensitive to noise and temporal fluctuations, necessitating extensive fine-tuning for downstream tasks. We introduce Brain-Semantoks, a self-supervised framework designed specifically to learn abstract representations of brain dynamics. Its architecture is built on two core innovations: a semantic tokenizer that aggregates noisy regional signals into robust tokens representing functional networks, and a self-distillation objective that enforces representational stability across time.

ICLR 2026 Poster accepted paper at ICLR 2026. As large language models (LLMs) continue to revolutionize AI research, there is a growing interest in building large-scale brain foundation models to advance neuroscience. While most existing brain foundation models are pre-trained on time-series signals or connectome features, we propose a novel graph-based pre-training paradigm for constructing a brain graph foundation model. In this paper, we introduce the Brain Graph Foundation Model, termed BrainGFM, a unified framework that leverages graph contrastive learning and graph masked autoencoders for large-scale fMRI-based pre-training. BrainGFM is pre-trained on a diverse mixture of brain atlases with varying parcellations, significantly expanding the pre-training corpus and enhancing the model’s ability to generalize across heterogeneous fMRI-derived brain representations. Code/project link: https://github.com/weixinxu666/BrainGFM

ICLR 2026 Poster accepted paper at ICLR 2026. Modeling the temporal dynamics of the human brain remains a core challenge in computational neuroscience and artificial intelligence. Traditional methods often ignore the biological spike characteristics of brain activity and find it difficult to reveal the dynamic dependencies and causal interactions between brain regions, limiting their effectiveness in brain function research and clinical applications. To address this issue, we propose a Spike-based Digital Brain (Spike-DB), a novel fundamental model that introduces the spike computing paradigm into brain time series modeling. Spike-DB encodes fMRI signals as spike trains and learns the temporal driving relationships between anchor and target regions to achieve high-precision prediction of brain activity and reveal underlying causal dependencies and dynamic relationship characteristics. Code/project link: https://github.com/UAIBC-Brain/Spike-DB

ICLR 2026 Poster accepted paper at ICLR 2026. Neural encoding models aim to predict fMRI-measured brain responses to natural images. fMRI data is acquired as a 3D volume of voxels, where each voxel has a defined spatial location in the brain. However, conventional encoding models often flatten this volume into a 1D vector and treat voxel responses as independent outputs. This removes spatial context, discards anatomical information, and ties each model to a subject-specific voxel grid. We introduce the NRF Neural Response Function, a framework that models fMRI activity as a continuous function over anatomical space rather than a flat vector of voxels. NRF represents brain activity as a continuous implicit function: given an image and a spatial coordinate (x, y, z) in standardized MNI space, the model predicts the response at that location.

ICLR 2026 Poster accepted paper at ICLR 2026. Enabling natural communication through brain–computer interfaces (BCIs) remains one of the most profound challenges in neuroscience and neurotechnology. While existing frameworks offer partial solutions, they are constrained by oversimplified semantic representations and a lack of interpretability. To overcome these limitations, we introduce **Semantic Intent Decoding(SID)**, a novel framework that translates neural activity into natural language by modeling meaning as a flexible set of compositional semantic units. SID is built on three core principles: semantic compositionality, continuity and expandability of semantic space, and fidelity in reconstruction.

ICLR 2026 Poster accepted paper at ICLR 2026. Epilepsy affects over 50 million people worldwide, and one-third of patients suffer drug-resistant seizures where surgery offers the best chance of seizure freedom. Accurate localization of the epileptogenic zone (EZ) relies on intracranial EEG (iEEG). Clinical workflows, however, remain constrained by labor-intensive manual review. At the same time, existing data-driven approaches are typically developed on single-center datasets that are inconsistent in format and metadata, lack standardized benchmarks, and rarely release pathological event annotations, creating barriers to reproducibility, cross-center validation, and clinical relevance. Code/project link: https://omni-ieeg.github.io/omni-ieeg/; https://github.com/Omni-iEEG/Omni-iEEG